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This volume details the history of Retinitis Pigmentosa and current treatment options. Chapters guide readers through CRISPR, gene therapy, stem cell therapy, next-generation sequencing methods, gene editing, and translational applications of other therapies to the treatment of Retinitis Pigmentosa. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the nece...

This volume details the history of Retinitis Pigmentosa and current treatment options. Chapters guide readers through CRISPR, gene therapy, stem cell therapy, next-generation sequencing methods, gene editing, and translational applications of other therapies to the treatment of Retinitis Pigmentosa. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the nece...

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Doctor Strange and the Midnight Sons are under siege — and Strange is transformed! Now the masked mystery magician known as Strange tests his sorcery against Doctor Doom and Namor! Clea returns, the Hulk is possessed and the sinister Salomé makes her move. But what is the connection between Strange and Dr. Vincent Stephens? And will the real Sorcerer Supreme please stand up? As Strange masters the power of catastrophe magic, Baron Mordo plots ...

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Peter Quinn's extraordinarily fine and ingenious novel, Banished Children of Eve, shows how much we are made of history . . . Unflinching in its depiction of prejudice and, for that matter, of grace, Quinn deftly weaves the lives of his characters into an intricate web of past and present, of association and moral involvement, until I, at least, had a sense not only of this terrible time but of history itself at the fundamental level, of the i...

This book explores the different forms and potential uses of genetic testing. Drawing together leading experts in disability law, bioethics and genetic discrimination, it highlights the ethical and legal challenges arising as a result of emerging and rapidly advancing genetic science. Chapters in the book ask whether the US Genetic Information Non-Discrimination Act (GINA) is proving to be an effective tool in addressing the issue of genetic d...

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The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif­ ferent functions that membranes perform. Nevertheless, the task ...

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as depo...

Judge Joe Crater's disappearance in 1930 spawns countless conspiracy theories and captures the imagination of a nation caught in the grip of The Depression. Fifteen years later, Detective Fintan Dunne answers a summons to New York where he is asked to solve the old case.

On the eve of World War II, a murder in New York City draws two vastly different men, an American detective and a German intelligence officer, into the gathering storm.The death of a spinster nurse killed in her apartment was one of hundreds of simple homicides, indistinguishable from any other in 1938. A suspect was caught and convicted. Then Private Investigator Fintan Dunne is lured in to the case, and coerced by conscience into unraveling ...

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As genetic technologies advance, genetic testing may well offer the prospect of detecting the onset of future disabilities. Some research also forwards that certain behavioural profiles may have a strong genetic basis, such as the determination to succeed, or the propensity for risk-taking. As this technology becomes more prevalent, there is a danger that genetic information may be misused by third parties and that particular genetic profiles ...